New polyketides and sesquiterpenoids from the deep-sea sulphide-derived fungus Phoma sp. 3A00413

Dandan Pan; Shan Lin; Xiaomei Huang; Dongli Lv; Qiliang Lai; Jinmei Xia; Zongze Shao; Weiyi Wang

doi:10.1016/j.fitote.2023.105546

New polyketides and sesquiterpenoids from the deep-sea sulphide-derived fungus Phoma sp. 3A00413

Fitoterapia. 2023 Jul:168:105546. doi: 10.1016/j.fitote.2023.105546. Epub 2023 May 20.

Authors

Dandan Pan¹, Shan Lin², Xiaomei Huang³, Dongli Lv⁴, Qiliang Lai¹, Jinmei Xia⁵, Zongze Shao¹, Weiyi Wang⁶

Affiliations

¹ School of Advanced Manufacturing, Fuzhou University, Jinjiang 362251, China; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.
² Department of Orthopedics, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China; School of Medicine, Xiamen University, Xiamen 361102, China.
³ Department of Marine Biology, Xiamen Ocean Vocational College, Xiamen 361102, China.
⁴ Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.
⁵ School of Advanced Manufacturing, Fuzhou University, Jinjiang 362251, China; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China. Electronic address: xiajinmei@tio.org.cn.
⁶ School of Advanced Manufacturing, Fuzhou University, Jinjiang 362251, China; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China. Electronic address: wywang@tio.org.cn.

PMID: 37217021
DOI: 10.1016/j.fitote.2023.105546

Abstract

Phoma fungi are known to produce a diverse range of natural products which possess various biological activities such as antifungal, antimicrobial, insecticidal, cytotoxic, and immunomodulatory effects. In our present study, we have isolated two novel polyketides (1 and 3), one new sesquiterpenoid (2), and eight known compounds (4-11) from the culture of Phoma sp. 3A00413, a deep-sea sulphide-derived fungus. The structures of compounds 1-3 were elucidated using NMR, MS, NMR calculation, and ECD calculation. In vitro antibacterial activities of all the isolated compounds were evaluated against Escherichia coli, Vibrio parahaemolyticus vp-HL, Vibrio parahaemolyticus, Staphylococcus aureus, Vibrio vulnificus, and Salmonella enteritidis. Compounds 1, 7, and 8 exhibited weak inhibition against Staphylococcus aureus growth, while compounds 3 and 7 showed weak inhibition against Vibrio vulnificus growth. Importantly, compound 3 demonstrated exceptional potency against Vibrio parahaemolyticus, with a minimum inhibitory concentration (MIC) of 3.1 μM.

Keywords: Antibacterial; Phoma; Polyketides; Sesquiterpenoids.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Phoma* / chemistry
Polyketides* / chemistry
Polyketides* / isolation & purification
Polyketides* / pharmacology
Sesquiterpenes* / chemistry
Sesquiterpenes* / isolation & purification
Sesquiterpenes* / pharmacology

Substances

Anti-Bacterial Agents
Polyketides
Sesquiterpenes