The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Yuhao Zhou; Shucheng Hua; Lei Song

doi:10.3389/fcimb.2023.1180708

The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Front Cell Infect Microbiol. 2023 May 5:13:1180708. doi: 10.3389/fcimb.2023.1180708. eCollection 2023.

Authors

Yuhao Zhou^{1

2}, Shucheng Hua^{1

2}, Lei Song^{1

2}

Affiliations

¹ Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
² State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, China.

Abstract

As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy. Recent research has shown that p62 is crucial in eradicating intracellular bacteria by xenophagy, a selective autophagic process that identifies and eliminates such microorganisms. This review highlights the various roles of p62 in intracellular bacterial infections, including both direct and indirect, antibacterial and infection-promoting aspects, and xenophagy-dependent and independent functions, as documented in published literature. Additionally, the potential applications of synthetic drugs targeting the p62-mediated xenophagy mechanism and unresolved questions about p62's roles in bacterial infections are also discussed.

Keywords: bacterial protein; intracellular bacterial infection; microdomain; p62 (sequestosome 1(SQSTM1); xenophagy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autophagy*
Bacterial Infections*
Humans
Sequestosome-1 Protein* / metabolism

Substances

Sequestosome-1 Protein
SQSTM1 protein, human

Grants and funding

The study was funded by National Natural Science Foundation of China grant 32270185, the State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science grant SKLPBS2132 and Science Development Project of Jilin province (20220303001SF).