Role of Exosomes in the Invasion and Metastasis of Ovarian Cancer and Application Potential of Clinical Diagnosis and Treatment

Yifei Zhu; Cheng Wang; Ziyu Ma; Feifei Li; Chunwei Xu; Weiwei Pan; Aijun Liu

doi:10.7150/jca.83663

Role of Exosomes in the Invasion and Metastasis of Ovarian Cancer and Application Potential of Clinical Diagnosis and Treatment

J Cancer. 2023 Apr 17;14(7):1141-1150. doi: 10.7150/jca.83663. eCollection 2023.

Authors

Yifei Zhu^{1

2}, Cheng Wang^{1

2}, Ziyu Ma², Feifei Li², Chunwei Xu³, Weiwei Pan⁴, Aijun Liu²

Affiliations

¹ Department of Pathology, School of Basic Medical Science, Weifang Medical University, Weifang 261053, China.
² Department of Pathology, Seventh Medical Center, General Hospital of PLA, Beijing 100700, China.
³ Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou 310022, China.
⁴ Department of Cell biology, College of Medicine, Jiaxing University, Jiaxing 314001, China.

Abstract

Ovarian cancer is a highly lethal form of cancer in females, largely due to extensive metastases that often accompany the initial diagnosis. Exosomes are microvesicles size from 30 to 100nm, which can be secreted by most cells. These special extracellular vesicles play a vital role in the metastasis of ovarian cancer. In this study, we conducted a comprehensive review of current research pertaining to the role of exosomes in ovarian cancer, utilizing the PubMed^® and Web of Science databases. Our review highlights the progress in elucidating the mechanisms by which exosomes facilitate ovarian cancer progression. Additionally, we discuss the potential of exosomes as a novel therapeutic target for ovarian cancer treatment. Overall, our review provides valuable insights into the current state of research on exosomes in ovarian cancer therapy.

Keywords: Ovarian cancer; cancer therapy; drug carrier; exosome; metastasis.

Publication types

Review