Advances in epidemiological status and pathogenesis of dental fluorosis

Kaiqiang Zhang; Zhenfu Lu; Xiaoying Guo

doi:10.3389/fcell.2023.1168215

Advances in epidemiological status and pathogenesis of dental fluorosis

Front Cell Dev Biol. 2023 May 5:11:1168215. doi: 10.3389/fcell.2023.1168215. eCollection 2023.

Authors

Kaiqiang Zhang¹, Zhenfu Lu¹, Xiaoying Guo²

Affiliations

¹ Department of Preventive Dentistry, School of Stomatology, China Medical University, Shenyang, Liaoning, China.
² Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, China.

Abstract

Fluoride is commonly consider as a "double-edged sword" because low consumption of fluoride can effectively prevent dental caries, but excessive consumption of fluoride can cause fluorosis. Dental fluorosis (DF) is a characteristic feature of fluorosis in the oral cavity that is manifested as tooth color changes and evident enamel defect. Presently, the pathogenesis of DF remains unclear. Herein, we have summarized the research progress in the pathogenesis and mechanism of DF in the past 5 years.

Keywords: dental fluorosis; epidemiology; molecular mechanism; pathogenesis; signal pathway.

Publication types

Review

Grants and funding

This work was supported by a grant from the National Natural Science Foundation of China (NSFC) (No. 82073497).