Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets

Fanzhen Yu; Yilong Teng; Jiaqi Li; Shutong Yang; Zeng Zhang; Yanming He; Hongjie Yang; Chuan-Fan Ding; Ping Zhou

doi:10.1021/acsomega.3c02200

Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets

ACS Omega. 2023 May 5;8(19):17304-17316. doi: 10.1021/acsomega.3c02200. eCollection 2023 May 16.

Authors

Fanzhen Yu¹, Yilong Teng¹, Jiaqi Li¹, Shutong Yang², Zeng Zhang³, Yanming He³, Hongjie Yang³, Chuan-Fan Ding⁴, Ping Zhou¹

Affiliations

¹ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
² Department of Chemistry, Fudan University, Shanghai 200433, China.
³ Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P. R. China.
⁴ Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, China.

Abstract

Type 2 diabetes (T2D) results from both insulin resistance and pancreatic β-cell dysfunction. A natural proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating insulin resistance in previous work. In this work, a T2D rat model induced by streptozocin (STZ) and a high-fat diet was used to investigate the effects of FYGL on pancreatic functions, and the transcriptomics of the rat pancreas was used to investigate the biological processes (BP) and signal pathways influenced by FYGL on the gene basis. Furthermore, the results of transcriptomics were verified both by histopathological analyses and protein expression. The studies showed that FYGL positively regulated T2D-related BP and signaling pathways and recovered the pancreatic function, therefore ameliorating hyperglycemia and hyperlipidemia in vivo. Importantly, the recovery of the pancreatic function suggested a crucial strategy to radically treat T2D.