Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES

Cuiling Wu; Chenxia Ren; Yingda Song; Huifang Gao; Xin Pang; Lianyun Zhang

doi:10.3389/fendo.2023.1148417

Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES

Front Endocrinol (Lausanne). 2023 May 4:14:1148417. doi: 10.3389/fendo.2023.1148417. eCollection 2023.

Authors

Cuiling Wu¹, Chenxia Ren², Yingda Song^{3

4}, Huifang Gao¹, Xin Pang¹, Lianyun Zhang¹

Affiliations

¹ Department of Biochemistry, Changzhi Medical College, Changzhi, China.
² Central Laboratory, Changzhi Medical College, Changzhi, China.
³ Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
⁴ Fifth Clinical Medical College, Shanxi Medical University, Taiyuan, China.

Abstract

Background: The relationship between oxidative balance score (OBS) and diabetes remains poorly understood and may be gender-specific. We conducted a cross-sectional study to investigate the complex association between OBS and diabetes among US adults.

Methods: Overall, 5,233 participants were included in this cross-sectional study. The exposure variable was OBS, composed of scores for 20 dietary and lifestyle factors. Multivariable logistic regression, subgroup analysis, and restricted cubic spline (RCS) regression were applied to examine the relationship between OBS and diabetes.

Results: Compared to the lowest OBS quartile group (Q1), the multivariable-adjusted odds ratio (OR) (95% confidence interval (CI) for the highest OBS quartile group (Q4) was 0.602 (0.372-0.974) (p for trend = 0.007), and for the highest lifestyle, the OBS quartile group was 0.386 (0.223-0.667) (p for trend < 0.001). Moreover, gender effects were found between OBS and diabetes (p for interaction = 0.044). RCS showed an inverted-U relationship between OBS and diabetes in women (p for non-linear = 6e-04) and a linear relationship between OBS and diabetes in men.

Conclusions: In summary, high OBS was negatively associated with diabetes risk in a gender-dependent manner.

Keywords: adults; cross-sectional study; diabetes; gender; oxidative balance score.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Sectional Studies
Diabetes Mellitus* / epidemiology
Female
Humans
Male
Nutrition Surveys
Oxidative Stress*
Prevalence

Grants and funding

This work was supported by the academic leader of Changzhi Medical College (No. XS202002), a grant from the Health Research Project of Shanxi Province (NO. 2020132).