Comparison of Two Generations of Thoracic Aortic Stent Grafts and Their Impact on Aortic Stiffness in an Ex Vivo Porcine Model

Tim J Mandigers; Michele Conti; Sara Allievi; Francesca Dedola; Daniele Bissacco; Daniele Bianchi; Stefania Marconi; Maurizio Domanin; Joost A Van Herwaarden; Ferdinando Auricchio; Santi Trimarchi

doi:10.1016/j.ejvsvf.2023.04.001

Comparison of Two Generations of Thoracic Aortic Stent Grafts and Their Impact on Aortic Stiffness in an Ex Vivo Porcine Model

EJVES Vasc Forum. 2023 Apr 12:59:8-14. doi: 10.1016/j.ejvsvf.2023.04.001. eCollection 2023.

Authors

Affiliations

¹ Department of Vascular Surgery, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
² Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands.
³ Civil Engineering and Architecture Department, Università Degli Studi di Pavia, Pavia, Italy.
⁴ Clinical and Community Sciences Department, Università Degli Studi di Milano, Milan, Italy.

Abstract

Objective: Little is known about the cardiovascular changes after TEVAR and regarding the impact on aortic stiffness for different stent graft generations specifically, following changes in device design. The present study evaluated the stent graft induced aortic stiffening of two generations of the Valiant thoracic aortic stent graft.

Methods: This was an ex vivo porcine investigation using an experimental mock circulatory loop. Thoracic aortas of young healthy pigs were harvested and connected to the mock circulatory loop. At a 60 bpm heart rate and stable mean arterial pressure, baseline aortic characteristics were obtained. Pulse wave velocity (PWV) was calculated before and after stent graft deployment. Paired and independent sample t tests or their non-parametric alternatives were performed to test for differences where appropriate.

Results: Twenty porcine thoracic aortas were divided into two equal subgroups, in which a Valiant Captivia or a Valiant Navion stent graft was deployed. Both stent grafts were similar in diameter and length. Baseline aortic characteristics did not differ between the subgroups. Mean arterial pressure values did not change after either stent graft, while pulse pressures increased statistically significantly after Captivia (mean 44 ± 10 mmHg to 51 ± 13 mmHg, p = .002) but not after Navion. Mean baseline PWV increased after both Captivia (4.4 ± 0.6 m/s to 4.8 ± 0.7 m/s, p = .007) and Navion (4.6 ± 0.7 m/s to 4.9 ± 0.7 m/s, p = .002). There was no statistically significant difference in the mean percentage increase in PWV for either subgroup (8 ± 4% vs. 6 ± 4%, p = .25).

Conclusion: These experimental findings showed no statistically significant difference in the percentage increase of aortic PWV after either stent graft generation and confirm that TEVAR increases aortic PWV. As a surrogate for aortic stiffness, this calls for further improvements in future thoracic aortic stent graft designs regarding device compliance.

Keywords: Aortic stiffness; Captivia; Experimental investigation; Navion; Pulse wave velocity; Valiant.