Effect of tumor microenvironment on ferroptosis: inhibition or promotion

Zhengzhen Xia; Yi Quan

doi:10.3389/fonc.2023.1155511

Effect of tumor microenvironment on ferroptosis: inhibition or promotion

Front Oncol. 2023 May 5:13:1155511. doi: 10.3389/fonc.2023.1155511. eCollection 2023.

Authors

Zhengzhen Xia¹, Yi Quan^{1

2}

Affiliations

¹ The First Clinical Medical School, Guangdong Medical University, Zhanjiang, Guangdong, China.
² Department of Oncology Medical Center, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.

Abstract

Ferroptosis is a type of lipid peroxidation-induced, iron-dependent programmed cell death. Emerging evidence suggests that ferroptosis is intimately connected to tumorigenesis, development, treatment and plays a major role in tumor immune regulation. This study focused on the connection between ferroptosis and immune regulation, which may offer a theoretical basis for targeting ferroptosis and tumor immunotherapy.

Keywords: ferroptosis; lipid peroxidation; micro RNA; tumor immunotherapy; tumor microenvironment.

Publication types

Review