Association between dietary antioxidant capacity and atherosclerotic carotid stenosis in patients with ischemic stroke

Jizi Ma; Xuerong Jia; Yaqian Xia; Min Peng; Yantong Chen; Jingjing Cai; Xinfeng Liu; Gelin Xu

doi:10.1016/j.jstrokecerebrovasdis.2023.107148

Association between dietary antioxidant capacity and atherosclerotic carotid stenosis in patients with ischemic stroke

J Stroke Cerebrovasc Dis. 2023 Aug;32(8):107148. doi: 10.1016/j.jstrokecerebrovasdis.2023.107148. Epub 2023 May 20.

Authors

Jizi Ma¹, Xuerong Jia², Yaqian Xia³, Min Peng⁴, Yantong Chen⁵, Jingjing Cai⁵, Xinfeng Liu¹, Gelin Xu⁶

Affiliations

¹ Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China.
² Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China; Department of Neurology, Affiliated Jinling Hospital, Nanjing Medical University, Nanjing, China.
³ Department of Neurology, Affiliated Jinling Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology, Rugao People's Hospital, Rugao, China.
⁴ Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China; Department of Neurology, Affiliated First Hospital of Jinan University, Guangzhou, China.
⁵ Department of Neurology, Shenzhen Second People's Hospital, Shenzhen, China; First Affiliated Hospital of Shenzhen University, Shenzhen, China.
⁶ Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China; Department of Neurology, Shenzhen Second People's Hospital, Shenzhen, China; First Affiliated Hospital of Shenzhen University, Shenzhen, China. Electronic address: gelinxu@nju.edu.cn.

PMID: 37210776
DOI: 10.1016/j.jstrokecerebrovasdis.2023.107148

Abstract

Background and purpose: The aim of this study was to evaluate the relationship between dietary total antioxidant capacity (DTAC) and atherosclerotic carotid stenosis in patients with ischemic stroke.

Methods: Patients with acute ischemic stroke were consecutively enrolled. Daily food consumption was estimated by a semi-quantitative food frequency questionnaire (FFQ). DTAC was calculated based on classified food intake. Antioxidant potential value was measured by ferric-reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) methods. Evaluation of carotid artery stenosis was based on computed tomography angiography (CTA). Logistic regression was used to assess the relationship between DTAC and degree of carotid stenosis.

Results: Of the 608 enrolled, 232 patients (38.2%) had moderate or severe carotid stenosis. After adjusting for major confounding factors, FRAP (OR =0.640; 95% CI: 0.410-0.998; P =0.049) and ORAC (OR =0.625; 95% CI: 0.400-0.976; P =0.039) were associated with lower degree of carotid artery stenosis (third vs first tertile). Spearman analysis indicated that FRAP (r =-0.121, P =0.003) and ORAC (r =-0.147, P <0.001) were correlated with degree of carotid stenosis.

Conclusions: DTAC may influence the initiation and development of atherosclerosis, and, therefore, the risk of ischemic stroke.

Keywords: Atherosclerosis; Carotid stenosis; Dietary antioxidant capacity; Ischemic stroke; Oxygen radical absorbance capacity.

MeSH terms

Angiography
Antioxidants
Atherosclerosis*
Carotid Stenosis* / complications
Carotid Stenosis* / diagnostic imaging
Humans
Iron
Ischemic Stroke*

Substances

Antioxidants
Iron