Another piece in the puzzle of kidney fibrosis

Andrea Remuzzi; Masaomi Nangaku

doi:10.1016/j.kint.2023.03.028

Another piece in the puzzle of kidney fibrosis

Kidney Int. 2023 Jun;103(6):1020-1023. doi: 10.1016/j.kint.2023.03.028.

Authors

Andrea Remuzzi¹, Masaomi Nangaku²

Affiliations

¹ Department of Management, Information and Production Engineering, University of Bergamo, Dalmine (BG), Italy. Electronic address: andrea.remuzzi@unibg.it.
² Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

PMID: 37210192
DOI: 10.1016/j.kint.2023.03.028

Abstract

Kidney fibrosis is a chronic physiomorphologic transformation of the renal parenchyma. Despite the known characteristics of the related structural and cellular changes, the mechanisms responsible for the initiation and progression of renal fibrosis are not completely understood. Development of efficient therapeutic drugs aimed at preventing the progressive loss of renal function requires an in-depth understanding of the complex phenomena associated with the pathophysiology of human diseases. The investigation of Li et al. provides novel evidence in this direction.

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MeSH terms

Fibrosis
Humans
Kidney / pathology
Kidney Diseases* / etiology
Kidney Diseases* / pathology
Myofibroblasts / pathology
Renal Insufficiency, Chronic* / etiology
Renal Insufficiency, Chronic* / pathology