Corded and hyalinized endometrioid carcinoma: Summary of clinical, histological, immunohistochemical and molecular data

Antonio Travaglino; Damiano Arciuolo; Angela Santoro; Antonio Raffone; Diego Raimondo; Paolo Casadio; Renato Seracchioli; Caterina Fulgione; Maurizio Guida; Antonio Mollo; Frediano Inzani; Gian Franco Zannoni

doi:10.1016/j.prp.2023.154515

Corded and hyalinized endometrioid carcinoma: Summary of clinical, histological, immunohistochemical and molecular data

Pathol Res Pract. 2023 Jul:247:154515. doi: 10.1016/j.prp.2023.154515. Epub 2023 May 8.

Authors

Affiliations

¹ Pathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Pathology Unit, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
² Pathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Department of Life Health and Public Health, Catholic University of the Sacred Hearth, Rome, Italy.
³ Pathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
⁴ Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. Electronic address: anton.raffone@gmail.com.
⁵ Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
⁶ Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
⁷ Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University of Naples, Naples, Italy.
⁸ Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Italy.
⁹ Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.

PMID: 37209572
DOI: 10.1016/j.prp.2023.154515

Abstract

Corded and hyalinized endometrioid carcinoma (CHEC) represents a potential pitfall for pathologists. This study aimed to provide a complete overview of all clinicopathological and molecular features of CHEC. Electronic databases were searched for all published series of CHEC. Clinical, histological, immunohistochemical and molecular data about CHEC were extracted and pooled. Six studies with 62 patients were identified; mean age was 49.8 years (range 19-83). Most cases showed FIGO stage I (68%), low grade (87.5%), and a favorable outcome (78.4%), with "no specific molecular profile" (NSMP). A subset of cases showed high-grade features (12.5%), p53 abnormalities (11.1%) or mismatch repair (MMR) deficiency (20%) and occurred at an older age (mean age>60 years). Common features of CHEC were: superficial localization of the corded component (88.6%), squamous/morular differentiation (82.5%), nuclear β-catenin accumulation (92%), partial/total loss of CKAE1/AE3 (88.9%), estrogen receptor (95.7%) and e-cadherin (100%), stromal changes such as myxoid (38.5%), osteoid (24%) and chondroid (4.5%), CTNNB1 mutations (57.9%), and POLE-wild-type (100%); 24.4% of cases showed lymphovascular space invasion. A minority of cases (16.2%) showed poor outcome despite a low-grade, NSMP phenotype; the molecular basis for the aggressiveness of these cases is still undefined. Further studies are necessary in this field.

Keywords: Carcinosarcoma; Corded and hyalinized; Endometrial carcinoma; Molecular; TCGA.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Carcinoma, Endometrioid* / genetics
Carcinoma, Endometrioid* / pathology
Endometrial Neoplasms* / genetics
Endometrial Neoplasms* / pathology
Female
Humans

Substances

Biomarkers, Tumor