Effect of OR51E1 single nucleotide polymorphisms on glioma susceptibility in the Chinese Han population

Jie Wei; Huan Zhang; Xiaoya Ma; Yujie Li; Wenqian Zhou; Jinping Guo; Tianbo Jin; Mingjun Hu

doi:10.1016/j.gene.2023.147489

Effect of OR51E1 single nucleotide polymorphisms on glioma susceptibility in the Chinese Han population

Gene. 2023 Jul 30:875:147489. doi: 10.1016/j.gene.2023.147489. Epub 2023 May 17.

Authors

Jie Wei¹, Huan Zhang¹, Xiaoya Ma¹, Yujie Li¹, Wenqian Zhou¹, Jinping Guo¹, Tianbo Jin², Mingjun Hu³

Affiliations

¹ College of Life Sciences, Northwest University, Xi'an 710069, Shaanxi, China; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an 710069, Shaanxi, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an 710069, Shaanxi, China.
² School of Medicine, Northwest University, Xi'an 710069, Shaanxi, China; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an 710069, Shaanxi, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an 710069, Shaanxi, China.
³ School of Medicine, Northwest University, Xi'an 710069, Shaanxi, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an 710069, Shaanxi, China; Department of Neurosurgery, Xi'an Chest Hospital, Xi'an 710100, Shaanxi, China; Department of Neurosurgery, Xi'an Changan District Hospital, Xi'an 710199, China. Electronic address: slhmj@tom.com.

PMID: 37207826
DOI: 10.1016/j.gene.2023.147489

Abstract

Background: Glioma is one of the common primary intracranial tumors, which is heterogeneous among individuals with a low cure rate. Our study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population.

Methods: A total of six SNPs on OR51E1 in 1,026 subjects (526 cases and 500 controls) were genotyped by MassARRAY iPLEX GOLD assay. The association between these SNPs and glioma susceptibility was analyzed using logistic regression, and odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated. The multifactor dimensionality reduction (MDR) method was applied to detect "SNP-SNP" interactions.

Results: In the overall sample, polymorphisms rs10768148, rs7102992, and rs10500608 were identified to be associated with glioma risk. In the stratified analysis based on gender, only polymorphism rs10768148 was observed to be associated with the risk of glioma. In the age-stratified analysis, rs7102992, rs74052483, and rs10500609 contributed to the risk of glioma in subjects aged > 40 years. And polymorphisms rs10768148 and rs7102992 were associated with the risk of glioma in subjects aged ≤ 40 years and subjects with astrocytoma. In addition, a strong synergistic relationship between rs74052483 and rs10768148, and a strong redundant relationship between rs7102992 and rs10768148 were identified in the study.

Conclusions: This study demonstrated the association of OR51E1 polymorphisms with glioma susceptibility, providing a basis for assessing glioma risk-associated variants in the Chinese Han population.

Keywords: Glioma; OR51E1; Single nucleotide polymorphisms; Susceptibility.

MeSH terms

Case-Control Studies
China
East Asian People
Genetic Predisposition to Disease
Genotype
Glioma* / genetics
Humans
Polymorphism, Single Nucleotide*
Receptors, G-Protein-Coupled / genetics

Substances

OR51E1 protein, human
Receptors, G-Protein-Coupled