Weaponizing the proteasome to overcome antimalarial drug resistance

Zhangping Xiao; Janine L Gray; Edward W Tate

doi:10.1016/j.chembiol.2023.04.012

Weaponizing the proteasome to overcome antimalarial drug resistance

Cell Chem Biol. 2023 May 18;30(5):415-417. doi: 10.1016/j.chembiol.2023.04.012.

Authors

Zhangping Xiao¹, Janine L Gray¹, Edward W Tate²

Affiliations

¹ Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
² Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK. Electronic address: e.tate@imperial.ac.uk.

PMID: 37207629
DOI: 10.1016/j.chembiol.2023.04.012

Abstract

In this issue of Cell Chemical Biology, Zhan et al. report dual-pharmacophore molecules ("artezomibs"), combining an artemisinin and proteasome inhibitor that exhibit potent activity against both wild-type and drug-resistant malarial parasites.¹ This study indicates that artezomibs offer a promising approach to combat drug resistance encountered by current antimalarial therapies.

Publication types

Comment

MeSH terms

Antimalarials* / chemistry
Drug Resistance
Proteasome Endopeptidase Complex
Proteasome Inhibitors / chemistry
Proteasome Inhibitors / pharmacology

Substances

Antimalarials
Proteasome Endopeptidase Complex
Proteasome Inhibitors