Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

Billy Wai-Lung Ng; Tongyang Xu; Zhihao Guo

doi:10.1016/j.molcel.2023.04.028

Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

Mol Cell. 2023 May 18;83(10):1544-1546. doi: 10.1016/j.molcel.2023.04.028.

Authors

Billy Wai-Lung Ng¹, Tongyang Xu², Zhihao Guo²

Affiliations

¹ School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: billyng@cuhk.edu.hk.
² School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

PMID: 37207621
DOI: 10.1016/j.molcel.2023.04.028

Abstract

Most human proteins lack small-molecule ligands, rendering these proteins "undruggable." In this issue of Molecular Cell, Lazear et al.¹ develop a novel chemical proteomic screening platform and discover new chemical probes targeting previously undruggable protein complexes.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromatography, Gel
Humans
Proteins* / metabolism
Proteomics* / methods

Substances

Proteins