Lipid metabolism in tumor immunology and immunotherapy

Lisa K Duong; Halil Ibrahim Corbali; Thomas S Riad; Shonik Ganjoo; Selene Nanez; Tiffany Voss; Hampartsum Barsomium; James Welsh; Maria Angelica Cortez

doi:10.3389/fonc.2023.1187279

Lipid metabolism in tumor immunology and immunotherapy

Front Oncol. 2023 May 2:13:1187279. doi: 10.3389/fonc.2023.1187279. eCollection 2023.

Authors

Lisa K Duong¹, Halil Ibrahim Corbali^{1

2}, Thomas S Riad¹, Shonik Ganjoo¹, Selene Nanez¹, Tiffany Voss¹, Hampartsum Barsomium¹, James Welsh¹, Maria Angelica Cortez¹

Affiliations

¹ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
² Department of Medical Pharmacology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Türkiye.

Abstract

Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.

Keywords: cancer; immune cells; immunotherapy; lipid oxidation; lipids.

Publication types

Review

Grants and funding

This work was supported U.S. Department of Defense (DOD) Lung Cancer Research Program (LRP; W81XWH-21-1-0336) to MC and by Cancer Center Support (Core) Grant P30 CA011672 from the National Cancer Institute, National Institutes of Health, to The University of Texas MD Anderson Cancer Center ({I:PW Pisters).