We isolated 5 highly pathogenic avian influenza A(H5N1) clade 2.3.4.4.b viruses from wild waterfowl feces in South Korea during November 2022. Whole-genome sequencing and phylogenetic analysis revealed novel genotypes produced by reassortment with Eurasian low pathogenicity avian influenza viruses. Enhanced surveillance will be required to improve prevention and control strategies.
Keywords: H5N1; South Korea; clade 2.3.4.4b; highly pathogenic avian influenza virus; influenza; phylogenetic analysis; respiratory infections; viruses; wild birds; zoonoses.