Nonanaphylactic Variant of Alpha-Gal Syndrome as an Etiology for Chronic Gastrointestinal Symptoms in Children

J Pediatr. 2023 Aug:259:113486. doi: 10.1016/j.jpeds.2023.113486. Epub 2023 May 17.

Abstract

We report 3 pediatric patients who presented with only nonanaphylactic symptoms of alpha-gal syndrome. This report highlights the necessity of not discounting alpha-gal syndrome from a differential diagnosis for patients with recurrent gastrointestinal distress and emesis after consuming mammalian meat, even in the absence of an anaphylactic reaction.

Keywords: abdominal pain; tick bite.

MeSH terms

  • Anaphylaxis* / etiology
  • Animals
  • Child
  • Food Hypersensitivity* / complications
  • Food Hypersensitivity* / diagnosis
  • Humans
  • Immunoglobulin E
  • Mammals
  • Tick Bites* / complications

Substances

  • Immunoglobulin E

Supplementary concepts

  • red meat allergy