Failure to Normalize Biventricular Function Is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia

Lisa S Le; John P Kinsella; Jason Gien; Benjamin S Frank

doi:10.1016/j.jpeds.2023.113490

Failure to Normalize Biventricular Function Is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia

J Pediatr. 2023 Sep:260:113490. doi: 10.1016/j.jpeds.2023.113490. Epub 2023 May 16.

Authors

Lisa S Le¹, John P Kinsella², Jason Gien², Benjamin S Frank³

Affiliations

¹ Heart Institute, Children's Hospital Colorado, Aurora CO.
² Department of Pediatrics Section of Neonatology, University of Colorado, Aurora CO.
³ Department of Pediatrics Section of Cardiology, University of Colorado, Aurora CO. Electronic address: Benjamin.Frank@childrenscolorado.org.

PMID: 37201678
DOI: 10.1016/j.jpeds.2023.113490

Abstract

We examined postnatal echocardiograms for 62 infants with congenital diaphragmatic hernia born from 2014 through 2020. Left and right ventricular dysfunction on D0 were sensitive, whereas persistent dysfunction on D2 was specific for extracorporeal membrane oxygenation requirement. Biventricular dysfunction had the strongest association with extracorporeal membrane oxygenation. Serial echocardiography may inform prognosis in congenital diaphragmatic hernia.

Keywords: ECMO; left ventricular dysfunction; pulmonary hypertension; right ventricular dysfunction.

MeSH terms

Echocardiography
Extracorporeal Membrane Oxygenation*
Hernias, Diaphragmatic, Congenital* / complications
Hernias, Diaphragmatic, Congenital* / diagnostic imaging
Hernias, Diaphragmatic, Congenital* / therapy
Humans
Infant
Infant, Newborn
Prognosis
Retrospective Studies