Accelerated intermittent theta burst stimulation for major depressive disorder or bipolar depression: A systematic review and meta-analysis

Dong-Bin Cai; Zhen-Juan Qin; Xian-Jun Lan; Qi-Man Liu; Xiu-De Qin; Jian-Jun Wang; Roberto Goya-Maldonado; Xing-Bing Huang; Gabor S Ungvari; Chee H Ng; Wei Zheng; Yu-Tao Xiang

doi:10.1016/j.ajp.2023.103618

Accelerated intermittent theta burst stimulation for major depressive disorder or bipolar depression: A systematic review and meta-analysis

Asian J Psychiatr. 2023 Jul:85:103618. doi: 10.1016/j.ajp.2023.103618. Epub 2023 May 6.

Authors

Affiliations

¹ Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China; The Fourth Clinical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
² The Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, China.
³ The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
⁴ Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
⁵ University of Notre Dame Australia, Fremantle, Australia; Division of Psychiatry, School of Medicine, University of Western Australia/Graylands Hospital, Perth, Australia.
⁶ Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, Victoria, Australia. Electronic address: cng@unimelb.edu.au.
⁷ The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: zhengwei0702@163.com.
⁸ Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China; Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China. Electronic address: xyutly@gmail.com.

PMID: 37201381
DOI: 10.1016/j.ajp.2023.103618

Abstract

We aimed to systematically evaluate the clinical efficacy and safety of accelerated intermittent theta burst stimulation (aiTBS) for patients with major depressive disorder (MDD) or bipolar depression (BD). A random-effects model was adopted to analyze the primary and secondary outcomes using the Review Manager, Version 5.3 software. This meta-analysis (MA) identified five double-blind randomized controlled trials (RCTs) comprising 239 MDD or BD patients with a major depressive episode. Active aiTBS overperformed sham stimulation in the study-defined response. This MA found preliminary evidence that active aiTBS resulted in a greater response in treating major depressive episodes in MDD or BD patients than sham stimulation.

Keywords: Accelerated theta burst stimulation; Depression; Meta-analysis; Remission; Response.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Bipolar Disorder* / therapy
Depressive Disorder, Major* / therapy
Double-Blind Method
Humans
Randomized Controlled Trials as Topic
Transcranial Magnetic Stimulation / methods
Treatment Outcome