Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery

Jiayu Zhang; Xiaomeng Cai; Rui Dou; Chen Guo; Jiaruo Tang; Yi Hu; Hanqing Chen; Jun Chen

doi:10.1016/j.omtn.2023.04.019

Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery

Mol Ther Nucleic Acids. 2023 Apr 23:32:568-581. doi: 10.1016/j.omtn.2023.04.019. eCollection 2023 Jun 13.

Authors

Jiayu Zhang¹, Xiaomeng Cai¹, Rui Dou¹, Chen Guo², Jiaruo Tang¹, Yi Hu^{1

3}, Hanqing Chen², Jun Chen¹

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics and University of Chinese Academy of Sciences (UCAS), Chinese Academy of Sciences (CAS), Beijing 100049, P. R. China.
² Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China.
³ State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing 100730, P. R. China.

Abstract

The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs.

Keywords: MT: Delivery Strategies; Poly(β-amino) esters (PβAEs); gene delivery; polymer; vaccines.

Publication types

Review