Role of MOTS-c in the regulation of bone metabolism

Xuejie Yi; Guangxuan Hu; Yang Yang; Jing Li; Junjie Jin; Bo Chang

doi:10.3389/fphys.2023.1149120

Role of MOTS-c in the regulation of bone metabolism

Front Physiol. 2023 May 2:14:1149120. doi: 10.3389/fphys.2023.1149120. eCollection 2023.

Authors

Xuejie Yi¹, Guangxuan Hu², Yang Yang³, Jing Li⁴, Junjie Jin², Bo Chang²

Affiliations

¹ Social Science Research Center, Shenyang Sport University, Shenyang, Liaoning, China.
² School of Sports Health, Shenyang Sport University, Shenyang, Liaoning, China.
³ School of Kinesiology, Shanghai University of Sport, Shanghai, China.
⁴ School of Physical Education, Liaoning Normal University, Dalian, Liaoning, China.

Abstract

MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, it inhibits osteoclast production and mediates the regulation of bone metabolism and bone remodeling. Exercise effectively upregulates the expression of MOTS-c, but the specific mechanism of MOTS-c regulation in bone by exercise remains unclear. Therefore, this article reviewed the distribution and function of MOTS-c in the tissue, discussed the latest research developments in the regulation of osteoblasts and osteoclasts, and proposed potential molecular mechanisms for the effect of exercise on the regulation of bone metabolism. This review provides a theoretical reference for establishing methods to prevent and treat skeletal metabolic diseases.

Keywords: MOTS-c; bone; metabolism; movement presentation; osteoblast; osteoclast.

Publication types

Review