Mesenchymal Stem Cells as A New Approach for the Treatment of Multiple Sclerosis:A Literature Review :

Amirabbas Rostami; Yusef Abbasi; Sheida Jamalnia; Asma Asadian; Hossein Enani; Morteza Jafarinia

doi:10.31661/gmj.v11i.2529

Mesenchymal Stem Cells as A New Approach for the Treatment of Multiple Sclerosis:A Literature Review :

Galen Med J. 2022 Dec 17:11:e2529. doi: 10.31661/gmj.v11i.2529. eCollection 2022.

Authors

Amirabbas Rostami¹, Yusef Abbasi², Sheida Jamalnia³, Asma Asadian⁴, Hossein Enani⁵, Morteza Jafarinia⁶

Affiliations

¹ Department of Internal Medicine, Faculty of General Medicine, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.
² Department of Anatomy, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
³ Department of Nursing and Midwifery, Kazeroun Branch, Islamic Azad University, Kazeroun, Iran.
⁴ Clinical Research Development Unit, 9 Dey Educational Hospital, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
⁵ Faculty of Medicine, Islamic Azad University, Marand Branch, Marand, Iran.
⁶ Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Multiple sclerosis (MS) is a high-prevalence autoimmune and neurodegenerative disease that affects young adults. An ideal treatment for MS should have two characteristics. First, its immunosuppression and immunomodulation effects reduce the abnormal immune response, and second, it improves repair by enhancing intrinsic repair processes or even cell replacement. Most available therapies have the first characteristic. Recent studies have proposed mesenchymal stem cells (MSCs) as a new therapeutic candidate for MS. Different clinical trials and animal models of MS have shown the therapeutic effect of MSCs. In the current study, we reviewed the therapeutic effects of MSCs in the animal model and patients with MS.

Keywords: Human Leukocyte Antigen; Mesenchymal Stem Cells; Multiple Sclerosis.