The present study explored the relationship between intersectional microaggressions (racism and heterosexism) and psychological distress outcomes among a sample of 370 Black lesbian, gay, and bisexual (LGB) adults. Additionally, social support from family, friends, and significant others was examined as potential moderators. Results showed that intersectional microaggressions were associated with greater depression, anxiety, and stress. Also, a significant moderating effect for family social support was found, suggesting that Black LGB adults with higher family social support reported greater levels of depression and stress as their microaggression experiences increased compared to those with less family social support. These results highlight the deleterious effects of intersectional microaggressions on the health of Black LGB adults and important clinical considerations pertaining to the role of social support. (PsycInfo Database Record (c) 2023 APA, all rights reserved).