Mycobacterium tuberculosis induces host autophagic ferritin degradation for enhanced iron bioavailability and bacterial growth

Youchao Dai; Chuanzhi Zhu; Wei Xiao; Xinchun Chen; Yi Cai

doi:10.1080/15548627.2023.2213983

Mycobacterium tuberculosis induces host autophagic ferritin degradation for enhanced iron bioavailability and bacterial growth

Autophagy. 2024 Apr;20(4):943-945. doi: 10.1080/15548627.2023.2213983. Epub 2023 May 17.

Authors

Youchao Dai¹, Chuanzhi Zhu², Wei Xiao³, Xinchun Chen⁴, Yi Cai⁴

Affiliations

¹ Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
² Laboratory of Molecular Biology, Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing, China.
³ School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, Guangdong, China.

PMID: 37198940
PMCID: PMC11062391 (available on 2024-05-17)
DOI: 10.1080/15548627.2023.2213983

Abstract

Mtb, Mycobacterium tuberculosis; TB, tuberculosis; NCOA4, nuclear receptor coactivator 4; p38, p38 protein kinase; AKT1, AKT serine/threonine kinase 1; TRIM21, tripartite motif containing 21; FTH1, ferritin heavy chain 1; FTL, ferritin light chain; HERC2, HECT and RLD domain containing E3 ubiquitin protein ligase 2.

Keywords: HERC2; NCOA4; TIRM21; Tuberculosis; ferritin; ferritinophagy.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Autophagy* / physiology
Biological Availability
Ferritins* / metabolism
Humans
Iron* / metabolism
Mycobacterium tuberculosis* / metabolism
Tuberculosis / metabolism
Tuberculosis / microbiology
Tuberculosis / pathology

Substances

Ferritins
Iron