During the global efforts to prevent and control the COVID-19 pandemic, extensive research and development of SARS-CoV-2 vaccines using various technical approaches have taken place. Among these, vaccines based on adenovirus vector have gained substantial knowledge and experience in effectively combating potential emerging infectious diseases, while also providing novel ideas and methodologies for vaccine research and development (R&D). This comprehensive review focuses on the adenovirus vector technology platform in vaccine R&D, emphasizing the importance of mucosal immunity induced by adenoviral vector-based vaccine for COVID-19 prevention. Furthermore, it analyzes the key technical challenges and obstacles encountered in the development of vaccines based on the adenovirus vector technology platform, with the aim of providing valuable insights and references for researchers and professionals in related fields.
在应对新型冠状病毒（新冠病毒）感染大流行的过程中，全球研发出多种技术路线的新冠病毒疫苗，其中腺病毒载体新冠病毒疫苗的应用为未来有效应对新发传染病流行积累了更多经验，也为新型疫苗研发提供了新的思路和方法。本研究详细梳理了腺病毒载体技术平台在新型冠状病毒疫苗研发应用的进展，重点探讨了腺病毒载体新冠病毒疫苗诱导的黏膜免疫对于预防COVID-19的意义，分析了基于腺病毒载体技术平台的疫苗研发面临的主要技术问题与挑战，以期为该技术路线疫苗的研发和应用提供科学参考。.