From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Y David Seo; Jennifer A Wargo

doi:10.1016/j.xcrm.2023.101039

From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Cell Rep Med. 2023 May 16;4(5):101039. doi: 10.1016/j.xcrm.2023.101039.

Authors

Y David Seo¹, Jennifer A Wargo²

Affiliations

¹ Departments of Surgical Oncology and Genomic Medicine, MD Anderson Cancer Center, Houston, TX, USA.
² Departments of Surgical Oncology and Genomic Medicine, MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jwargo@mdanderson.org.

Abstract

Tintelnot et al.¹ identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

Published by Elsevier Inc.

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MeSH terms

Adenocarcinoma* / drug therapy
Animals
Bacteria
Mice
Pancreatic Neoplasms* / drug therapy