Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice"

Yuanyuan Wang; Martin Weber; Oded Foreman; Helga Remy; Eva Zsuzsanna Mracsko; Jesse E Hanson

doi:10.1126/scitranslmed.ade8728

Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice"

Sci Transl Med. 2023 May 17;15(696):eade8728. doi: 10.1126/scitranslmed.ade8728. Epub 2023 May 17.

Authors

Yuanyuan Wang¹, Martin Weber¹, Oded Foreman², Helga Remy³, Eva Zsuzsanna Mracsko³, Jesse E Hanson¹

Affiliations

¹ Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
² Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
³ Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

PMID: 37196063
DOI: 10.1126/scitranslmed.ade8728

Abstract

We highlight potential issues with a Western blot assay using mouse anti-caspase-1 antibody to detect cleaved caspase-1 p20 subunit in mouse brain tissue lysates.

MeSH terms

Animals
Inflammasomes*
Mice
Synucleinopathies*
alpha-Synuclein

Substances

Inflammasomes
alpha-Synuclein