SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27

Autophagy. 2023 Nov;19(11):3029-3030. doi: 10.1080/15548627.2023.2210943. Epub 2023 May 16.

Abstract

SQSTM1/p62: Sequestosome-1; HSP27: Heat shock protein 27; LLPS: liquid-liquid phase separation; iPSC: induced pluripotent stem cell; PB1: Phox and Bem1p; FRAP: fluorescence recovery after photo-bleaching; ATG: autophagy-related; ALS: amyotrophic lateral sclerosis.

Keywords: HSP27; Lysosomes; Sqstm1/P62; lysophagy; neurodegeneration; phase separation.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Amyotrophic Lateral Sclerosis* / metabolism
  • Autophagy
  • HSP27 Heat-Shock Proteins* / metabolism
  • Humans
  • Macroautophagy
  • Sequestosome-1 Protein / metabolism

Substances

  • Sequestosome-1 Protein
  • HSP27 Heat-Shock Proteins
  • SQSTM1 protein, human