The potential regulatory role of RNA methylation in ovarian cancer

Shijie Zhao; Mengxue Zhang; Xiaolan Zhu; Jie Xing; Jiaming Zhou; Xinming Yin

doi:10.1080/15476286.2023.2213915

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biol. 2023 Jan;20(1):207-218. doi: 10.1080/15476286.2023.2213915.

Authors

Shijie Zhao¹, Mengxue Zhang¹, Xiaolan Zhu², Jie Xing¹, Jiaming Zhou¹, Xinming Yin³

Affiliations

¹ Department of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
² Reproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
³ Department of Gynaecology, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.

Abstract

Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification. RNA methylation is essential for regulating biological processes such as RNA transcription, splicing, structure, stability, and translation. Its dysfunction is strongly associated with the development of human malignancies. Research advances with respect to the regulatory role of RNA modifications in ovarian cancer include N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and N7-methylguanosine (m7G). Numerous studies have demonstrated that epigenetic modifications of RNA can influence the progression and metastasis of ovarian cancer and may provide excellent targets for cancer therapy. This review highlights advances in research on RNA methylation modifications and ovarian cancer prognosis, carcinogenesis, and resistance, which could provide a theoretical foundation for designing therapeutic strategies for ovarian cancer based on RNA methylation modifications.

Keywords: M1a; M5c; M6a; M7g; RNA methylation; ovarian cancer.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Epigenesis, Genetic
Female
Humans
Methylation
Ovarian Neoplasms* / genetics
RNA* / chemistry
RNA* / genetics

Substances

RNA

Grants and funding

The work was supported by the National Natural Science Foundation of China [Grant Nos. 82172838, 81871343]; Natural Science Foundation of Jiangsu Province [Grant No. BK20201223]; Science and Technology Innovation Fund of Zhenjiang city [Grant No.SH2022048].