Short-term Follow-up of Autologous Adult Live-Cultured Osteoblasts Implantation in Avascular Necrosis of Femoral Head Secondary to Sickle Cell Anemia-Case Series

Alok Chandra Agrawal; Harshal Sakale; Ankit Kumar Garg; Anupam Inamdar

doi:10.13107/jocr.2023.v13.i04.3616

Short-term Follow-up of Autologous Adult Live-Cultured Osteoblasts Implantation in Avascular Necrosis of Femoral Head Secondary to Sickle Cell Anemia-Case Series

J Orthop Case Rep. 2023 Apr;13(4):57-61. doi: 10.13107/jocr.2023.v13.i04.3616.

Authors

Alok Chandra Agrawal¹, Harshal Sakale¹, Ankit Kumar Garg¹, Anupam Inamdar¹

Affiliation

¹ Department of Orthopaedics, All India Institute of Medical Sciences, Raipur, Chhatisgarh, India.

Abstract

Introduction: The prevalence of avascular necrosis (AVN) of the femoral head in sickle cell anemia is 50% whereas untreated cases lead to total hip replacement. The recent development in cellular therapy paves the way to utilize autologous adult live-cultured osteoblasts (AALCO) in the management of AVN of the femoral head secondary to sickle cell anemia.

Case report: We performed AALCO implantation in sickle cell anemia cases with AVN of the femoral head and were followed up for 6 months with the regular recording of visual analog score and modified Harris Hip Score.

Conclusion: AALCO implantation for the management of AVN of the femoral head due to sickle cell anemia appears to be the biological management of choice as it results in pain reduction and improvement in function.

Keywords: Osteonecrosis; cultured osteoblasts; femoral head; sickle cell anemia.

Publication types

Case Reports