Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing

Kuniaki Otsuka; Shougo Murakami; Kiyotaka Okajima; Koichi Shibata; Yutaka Kubo; Denis G Gubin; Larry A Beaty; Germaine Cornelissen

doi:10.2147/CIA.S398957

Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing

Clin Interv Aging. 2023 May 10:18:755-769. doi: 10.2147/CIA.S398957. eCollection 2023.

Authors

Kuniaki Otsuka^{1

2}, Shougo Murakami³, Kiyotaka Okajima⁴, Koichi Shibata¹, Yutaka Kubo⁵, Denis G Gubin^{6

7

8}, Larry A Beaty², Germaine Cornelissen²

Affiliations

¹ Tokyo Women's Medical University, Tokyo, Japan.
² Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA.
³ Department of Cardiovascular Medicine, Soseikai General Hospital, Kyoto, Japan.
⁴ Cardiovascular Internal Medicine, Higashi Omiya General Hospital, Saitama, Japan.
⁵ Department of Medicine, Machida Keisen Hospital, Tokyo, Japan.
⁶ Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Medical University, Tyumen, 625023, Russia.
⁷ Department of Biology, Medical University, Tyumen, 625023, Russia.
⁸ Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia.

Abstract

Background: Blood pressure (BP) variability is involved in the appraisal of threat and safety, and can serve as a potential marker of psychological resilience against stress. The relationship between biological rhythms of BP and resilience was cross-sectionally assessed by 7-day/24-hour chronobiologic screening in a rural Japanese community (Tosa), with focus on the 12-hour component and the "circadian-circasemidian coupling" of systolic (S) BP.

Subjects and methods: Tosa residents (N = 239, 147 women, 23-74 years), free of anti-hypertensive medication, completed 7-day/24-hour ambulatory BP monitoring. The circadian-circasemidian coupling was determined individually by computing the difference between the circadian phase and the circasemidian morning-phase of SBP. Participants were classified into three groups: those with a short coupling interval of about 4.5 hours (Group A), those with an intermediate coupling interval of about 6.0 hours (Group B), and those with a long coupling interval of about 8.0 hours (Group C).

Results: Residents of Group B who showed optimal circadian-circasemidian coordination had less pronounced morning and evening SBP surges, as compared to residents of Group A (10.82 vs 14.29 mmHg, P < 0.0001) and Group C (11.86 vs 15.21 mmHg, P < 0.0001), respectively. The incidence of morning or evening SBP surge was less in Group B than in Group A (P < 0.0001) or Group C (P < 0.0001). Group B residents showed highest measures of wellbeing and psychological resilience, assessed by good relation with friends (P < 0.05), life satisfaction (P < 0.05), and subjective happiness (P < 0.05). A disturbed circadian-circasemidian coupling was associated with elevated BP, dyslipidemia, arteriosclerosis and a depressive mood.

Conclusion: The circadian-circasemidian coupling of SBP could serve as a new biomarker in clinical practice to guide precision medicine interventions aimed at achieving properly timed rhythms, and thereby resilience and wellbeing.

Keywords: 12-hour morning acrophase; 7-day/24-hour chronobiologic screening; appropriate circadian-circasemidian coupling; biological 12-hour rhythm; blood pressure; circadian acrophase; evening blood pressure surge; human resilience; morning blood pressure surge; wellbeing.

MeSH terms

Adult
Aged
Aging / physiology
Blood Pressure* / physiology
Circadian Rhythm* / physiology
Female
Happiness
Humans
Male
Middle Aged
Monitoring, Physiologic*
Normal Distribution
Personal Satisfaction
Resilience, Psychological* / physiology
Sleep / physiology
Time Factors
Young Adult