High-level levofloxacin-resistant emm12 group A Streptococcus, 2012-2018: A multicenter study in Taiwan

Ying-Chi Huang; Jui-Fen Lai; Chi-Jung Wu; I-Wen Huang; Shu-Chen Kuo; Ching-Len Liao; Tzu-Wen Huang; Tsai-Ling Lauderdale

doi:10.1016/j.jmii.2023.04.010

High-level levofloxacin-resistant emm12 group A Streptococcus, 2012-2018: A multicenter study in Taiwan

J Microbiol Immunol Infect. 2023 Aug;56(4):875-879. doi: 10.1016/j.jmii.2023.04.010. Epub 2023 May 6.

Authors

Ying-Chi Huang¹, Jui-Fen Lai¹, Chi-Jung Wu², I-Wen Huang¹, Shu-Chen Kuo¹, Ching-Len Liao¹, Tzu-Wen Huang³, Tsai-Ling Lauderdale⁴

Affiliations

¹ National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan.
² National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
³ Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: tw.huang@tmu.edu.tw.
⁴ National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan. Electronic address: lauderdale@nhri.edu.tw.

PMID: 37188572
DOI: 10.1016/j.jmii.2023.04.010

Abstract

High-level levofloxacin-resistant group A Streptococcus emerged in Taiwan in 2012. Among the 24 isolates identified, 23 belonged to emm12/ST36, most harbored the same GyrA and ParC mutations and were highly clonal. wgMLST showed them to be closely related to the Hong Kong scarlet fever outbreak strains. Continuous surveillance is warranted.

Keywords: Group A Streptococcus; Levofloxacin-nonsusceptible; Streptococcus pyogenes; emm type; emm12.

Publication types

Multicenter Study

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial / genetics
Hong Kong
Humans
Levofloxacin / pharmacology
Microbial Sensitivity Tests
Scarlet Fever* / drug therapy
Scarlet Fever* / epidemiology
Streptococcal Infections* / drug therapy
Streptococcal Infections* / epidemiology
Streptococcus pyogenes
Taiwan / epidemiology

Substances

Levofloxacin
Anti-Bacterial Agents