Advances in the knowledge on the role of apoptosis repressor with caspase recruitment domain in hemorrhagic stroke

Xu Pei; Mi Tian; Yao Wang; Yuewen Xin; Junliang Jiang; Yunyun Wang; Ye Gong

doi:10.1016/j.jointm.2022.11.003

Advances in the knowledge on the role of apoptosis repressor with caspase recruitment domain in hemorrhagic stroke

J Intensive Med. 2023 Jan 2;3(2):138-143. doi: 10.1016/j.jointm.2022.11.003. eCollection 2023 Apr 30.

Authors

Xu Pei¹, Mi Tian¹, Yao Wang¹, Yuewen Xin¹, Junliang Jiang¹, Yunyun Wang¹, Ye Gong^{1

2}

Affiliations

¹ Department of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.

Abstract

The apoptosis repressor with caspase recruitment domain (ARC) plays a critical role in extrinsic apoptosis initiation via death receptor ligands, physiological stress, infection response in a tissue-dependent manner, endoplasmic reticulum (ER) stress, genotoxic drugs, ionizing radiation, oxidative stress, and hypoxia. Recent studies have suggested that regulating apoptosis-related pathways can improve outcomes for patients with neurological diseases, such as hemorrhagic stroke. ARC expression is significantly correlated with acute cerebral hemorrhage. However, the mechanism by which it mediates the anti-apoptosis pathway remains poorly known. Here, we discuss the function of ARC in hemorrhagic stroke and argue that it could serve as an effective target for the treatment of hemorrhagic stroke.

Keywords: Apoptosis repressor with caspase recruitment domain (ARC); Hemorrhagic stroke; Neuroinflammation; Neuronal apoptosis.

Publication types

Review