A flexible wearable device coupled with injectable Fe3O4 nanoparticles for capturing circulating tumor cells and triggering their deaths

Ya Li; Xinyu Liu; Yingying Zhang; Ziyue Wu; Wei Ling; Xinyu Zhang; Mingxing Zhou; M Serdar Onses; Pan Zhou; Sui Mao; Wenxing Huo; Zhenzhen Fan; Hong Yang; Hanjie Wang; Xian Huang

doi:10.1016/j.bios.2023.115367

A flexible wearable device coupled with injectable Fe₃O₄ nanoparticles for capturing circulating tumor cells and triggering their deaths

Biosens Bioelectron. 2023 Sep 1:235:115367. doi: 10.1016/j.bios.2023.115367. Epub 2023 May 10.

Authors

Ya Li¹, Xinyu Liu¹, Yingying Zhang², Ziyue Wu¹, Wei Ling¹, Xinyu Zhang³, Mingxing Zhou¹, M Serdar Onses⁴, Pan Zhou¹, Sui Mao¹, Wenxing Huo¹, Zhenzhen Fan⁵, Hong Yang⁶, Hanjie Wang⁷, Xian Huang⁸

Affiliations

¹ Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
² School of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China.
³ Department of Life Science, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.
⁴ Department of Materials Science and Engineering, Erciyes University, Talas Yolu Melikgazi, Kayseri, 38039, Turkey.
⁵ Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.
⁶ The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Sciences, School of Biomedical Engineering, Intensive Care Unit, The Second Hospital, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, China.
⁷ Department of Life Science, Tianjin University, 92 Weijin Road, Tianjin, 300072, China. Electronic address: wanghj@tju.edu.cn.
⁸ Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China; Institute of Wearable Technology and Bioelectronics, Qiantang Science and Technology Innovation Center, 1002 23rd Street, Hangzhou, 310018, China. Electronic address: huangxian@tju.edu.cn.

PMID: 37187061
DOI: 10.1016/j.bios.2023.115367

Abstract

Elimination of circulating tumor cells (CTCs) in the blood can be an effective therapeutic approach to disrupt metastasis. Here, a strategy is proposed to implement flexible wearable electronics and injectable nanomaterials to disrupt the hematogenous transport of CTCs. A flexible device containing an origami magnetic membrane is used to attract Fe₃O₄@Au nanoparticles (NPs) that are surface modified with specific aptamers and intravenously injected into blood vessels, forming an invisible hand and fishing line/bait configuration to specifically capture CTCs through bonding with aptamers. Thereafter, thinned flexible AlGaAs LEDs in the device offer an average fluence of 15.75 mW mm^-2 at a skin penetration depth of 1.5 mm, causing a rapid rise of temperature to 48 °C in the NPs and triggering CTC death in 10 min. The flexible device has been demonstrated for intravascular isolation and enrichment of CTCs with a capture efficiency of 72.31% after 10 cycles in a simulated blood circulation system based on a prosthetic upper limb. The fusion of nanomaterials and flexible electronics reveals an emerging field that utilizes wearable and flexible stimulators to activate biological effects offered by nanomaterials, leading to improved therapeutical effects and postoperative outcomes of diseases.

Keywords: Aptamer; Circulation tumor cells; Flexible electronics; Nanomaterials; Origami magnetic membranes.

MeSH terms

Biosensing Techniques*
Gold
Humans
Metal Nanoparticles*
Nanostructures*
Neoplastic Cells, Circulating*

Substances

Gold