Beyond pathogenesis: Detecting the full spectrum of ecological interactions in the virosphere

PLoS Biol. 2023 May 15;21(5):e3002109. doi: 10.1371/journal.pbio.3002109. eCollection 2023 May.

Abstract

The public perception of viruses has historically been negative. We are now at a stage where the development of tools to study viruses is at an all-time high, but society's perception of viruses is at an all-time low. The literature regarding viral interactions has been skewed towards negative (i.e., pathogenic) symbioses, whereas viral mutualisms remain relatively underexplored. Viral interactions with their hosts are complex and some non-pathogenic viruses could have potential benefits to society. However, viral research is seldom designed to identify viral mutualists, a gap that merits considering new experimental designs. Determining whether antagonisms, mutualisms, and commensalisms are equally common ecological strategies requires more balanced research efforts that characterize the full spectrum of viral interactions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Symbiosis
  • Viruses*

Grants and funding

SDJ was supported by a synthesis fellowship from the Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig, Germany (DFG–FZT 118, 202548816), specifically funding through sDiv, the Synthesis Centre of iDiv. EFYH was supported in part by NSF grants #1541538 (GoLife) and #1846376 (CAREER) and by a sabbatical fellowship from the Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig, Germany (DFG–FZT 118, 202548816). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.