Polyphenol-assisted assembly of Au-deposited polylactic acid microneedles for SERS sensing and antibacterial photodynamic therapy

Zi-Chun Chia; Yi-Lun Chen; Cheng-Hsun Chuang; Chou-Hsun Hsieh; Ya-Jyun Chen; Kuan-Hsu Chen; Tzu-Chi Huang; Mei-Chin Chen; Chih-Chia Huang

doi:10.1039/d3cc00733b

Polyphenol-assisted assembly of Au-deposited polylactic acid microneedles for SERS sensing and antibacterial photodynamic therapy

Chem Commun (Camb). 2023 May 23;59(42):6339-6342. doi: 10.1039/d3cc00733b.

Authors

Zi-Chun Chia¹, Yi-Lun Chen², Cheng-Hsun Chuang², Chou-Hsun Hsieh², Ya-Jyun Chen¹, Kuan-Hsu Chen¹, Tzu-Chi Huang¹, Mei-Chin Chen², Chih-Chia Huang^{1

3}

Affiliations

¹ Department of Photonics, National Cheng Kung University, Tainan 70101, Taiwan.
² Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan. kokola@mail.ncku.edu.tw.
³ Center of Applied Nanomedicine, National Cheng Kung University, Tainan 70101, Taiwan. c2huang@mail.ncku.edu.tw.

PMID: 37186113
DOI: 10.1039/d3cc00733b

Abstract

3D SERS microneedles with self-assembled AuNPs were fabricated with tannic acid (chemical glue and reductant) on polylactic acid microneedles for in-depth chemical and biomolecular analysis, with LOD values below 200 ppb for small molecules and 10² CFU cm^-2 for bacteria. The MB/Au-microneedles were used for photodynamic therapy with SERS-monitored photosensitizer degradation.

MeSH terms

Gold / chemistry
Metal Nanoparticles* / chemistry
Photochemotherapy*
Polyphenols
Spectrum Analysis, Raman

Substances

Gold
poly(lactide)
Polyphenols