Extracellular lncRNAs secreted and absorbed by cardiomyocytes

J Cell Biochem. 2023 Jun;124(6):785-796. doi: 10.1002/jcb.30425. Epub 2023 May 14.

Abstract

Exosomes are membrane-surrounded extracellular vesicles released by almost all cell types, which mediate intercellular communications by delivering bioactive molecules from secretory cells to recipient cells. Long noncoding RNAs (lncRNAs) are a large class of non-(protein)-coding RNAs with lengths exceeding 200 nucleotides that are very active in the development of cardiovascular diseases (CVDs). Increasing evidence suggests that exosomal lncRNAs also play important roles in the progress of CVDs. We focus on the current available studies regarding these extracellular lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, hopefully providing a basis for deeper understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.

Keywords: cardiomyocytes; cardiovascular diseases; exosomes; long noncoding RNAs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Cardiovascular Diseases* / metabolism
  • Exosomes* / genetics
  • Exosomes* / metabolism
  • Extracellular Vesicles* / genetics
  • Extracellular Vesicles* / metabolism
  • Humans
  • Myocytes, Cardiac / metabolism
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism

Substances

  • RNA, Long Noncoding