Surface functionalized nanoparticles: A boon to biomedical science

Kanchan Upadhyay; Raunak Kumar Tamrakar; Sabu Thomas; Manish Kumar

doi:10.1016/j.cbi.2023.110537

Surface functionalized nanoparticles: A boon to biomedical science

Chem Biol Interact. 2023 Aug 1:380:110537. doi: 10.1016/j.cbi.2023.110537. Epub 2023 May 12.

Authors

Kanchan Upadhyay¹, Raunak Kumar Tamrakar², Sabu Thomas³, Manish Kumar⁴

Affiliations

¹ Department of Applied Physics, Bhilai Institute of Technology (Seth Balkrishan Memorial), Near Bhilai House, Durg, C.G, 491001, India. Electronic address: kanchan.chemistry@gmail.com.
² Department of Applied Physics, Bhilai Institute of Technology (Seth Balkrishan Memorial), Near Bhilai House, Durg, C.G, 491001, India.
³ School of Energy Materials, Mahatma Gandhi University, Kottyam, Kerla, 686560, India.
⁴ Department of Mechanical Engineering, Bhilai Institute of Technology (Seth Balkrishan Memorial), Near Bhilai Power House, Durg, 49100, Chhattisgarh, India.

PMID: 37182689
DOI: 10.1016/j.cbi.2023.110537

Abstract

The rapid development of nanomedicine has increased the likelihood that manufactured nanoparticles will one day come into contact with people and the environment. A variety of academic fields, including engineering and the health sciences, have taken a keen interest in the development of nanotechnology. Any significant development in nanomaterial-based applications would depend on the production of functionalized nanoparticles, which are believed to have the potential to be used in fields like pharmaceutical and biomedical sciences. The functionalization of nanoparticles with particular recognition chemical moieties does result in multifunctional nanoparticles with greater efficacy while at the same time minimising adverse effects, according to early clinical studies. This is because of traits like aggressive cellular uptake and focused localization in tumours. To advance this field of inquiry, chemical procedures must be developed that reliably attach chemical moieties to nanoparticles. The structure-function relationship of these functionalized nanoparticles has been extensively studied as a result of the discovery of several chemical processes for the synthesis of functionalized nanoparticles specifically for drug delivery, cancer therapy, diagnostics, tissue engineering, and molecular biology. Because of the growing understanding of how to functionalize nanoparticles and the continued work of innovative scientists to expand this technology, it is anticipated that functionalized nanoparticles will play an important role in the aforementioned domains. As a result, the goal of this study is to familiarise readers with nanoparticles, to explain functionalization techniques that have already been developed, and to examine potential applications for nanoparticles in the biomedical sciences. This review's information is essential for the safe and broad use of functionalized nanoparticles, particularly in the biomedical sector.

Keywords: Cancer therapy; Drug delivery; Functionalization; Nano particles; Nanomedicine.

Publication types

Review

MeSH terms

Drug Delivery Systems / methods
Humans
Nanomedicine / methods
Nanoparticles* / chemistry
Nanostructures*
Nanotechnology / methods