Orthostatic hypotension and executive function in older people from the French MERE cohort attending a memory clinic

Guillaume T Duval; Marine Asfar; Jennifer Gautier; Cédric Annweiler

doi:10.1016/j.maturitas.2023.04.007

Orthostatic hypotension and executive function in older people from the French MERE cohort attending a memory clinic

Maturitas. 2023 Jul:173:16-19. doi: 10.1016/j.maturitas.2023.04.007. Epub 2023 May 3.

Authors

Guillaume T Duval¹, Marine Asfar², Jennifer Gautier³, Cédric Annweiler⁴

Affiliations

¹ Department of Geriatric Medicine, University Memory Center, Research Center on Autonomy and Longevity (CeRAL), Angers University Hospital, Angers, France; School of Medicine and UPRES EA 4638, University of Angers, Angers, France. Electronic address: guillaume.duval@chu-angers.fr.
² Department of Geriatric Medicine, University Memory Center, Research Center on Autonomy and Longevity (CeRAL), Angers University Hospital, Angers, France; School of Medicine and UPRES EA 4638, University of Angers, Angers, France.
³ Department of Geriatric Medicine, University Memory Center, Research Center on Autonomy and Longevity (CeRAL), Angers University Hospital, Angers, France.
⁴ Department of Geriatric Medicine, University Memory Center, Research Center on Autonomy and Longevity (CeRAL), Angers University Hospital, Angers, France; School of Medicine and UPRES EA 4638, University of Angers, Angers, France; Robarts Research Institute, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada.

PMID: 37182386
DOI: 10.1016/j.maturitas.2023.04.007

Abstract

Orthostatic hypotension (OH) seems to be implicated in cognitive impairment. Nevertheless, not all the cognitive functions affected by OH have been identified. Participants from the MERE cohort were evaluated for OH (i.e. drop in blood pressure ≥20 mmHg for systolic and ≥10 mmHg for diastolic between lying and standing) and executive functions, implicated in brain motor control, and evaluated with the Frontal Assessment Battery (FAB) and its sub-scores. Of the 1573 patients selected, 338 had OH (21.5 %). We found an inverse cross-sectional association between OH and linear FAB score and an association with the sub-score for the motor sequence of Luria. In the MERE cohort, OH was associated with executive function disorder and with a pathological motor sequence of Luria as a melo-kinetic praxis disorder.

Keywords: Cognition; Executive functions; Older adults; Orthostatic hypotension; Praxis.

MeSH terms

Aged
Blood Pressure
Cognition
Cognitive Dysfunction* / complications
Cognitive Dysfunction* / epidemiology
Cross-Sectional Studies
Executive Function
Humans
Hypotension, Orthostatic* / complications
Hypotension, Orthostatic* / psychology