Multiple functions and regulatory network of miR-150 in B lymphocyte-related diseases

Yue-Zi Hu; Qiao Li; Peng-Fei Wang; Xue-Ping Li; Zhao-Lan Hu

doi:10.3389/fonc.2023.1140813

Multiple functions and regulatory network of miR-150 in B lymphocyte-related diseases

Front Oncol. 2023 Apr 27:13:1140813. doi: 10.3389/fonc.2023.1140813. eCollection 2023.

Authors

Yue-Zi Hu¹, Qiao Li², Peng-Fei Wang², Xue-Ping Li³, Zhao-Lan Hu²

Affiliations

¹ Clinical Laboratory, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.
² Department of Anesthesiology, The Second Affiliated Xiangya Hospital, Central South University, Changsha, China.
³ Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, United States.

Abstract

MicroRNAs (miRNAs) play vital roles in the post-transcriptional regulation of gene expression. Previous studies have shown that miR-150 is a crucial regulator of B cell proliferation, differentiation, metabolism, and apoptosis. miR-150 regulates the immune homeostasis during the development of obesity and is aberrantly expressed in multiple B-cell-related malignant tumors. Additionally, the altered expression of MIR-150 is a diagnostic biomarker of various autoimmune diseases. Furthermore, exosome-derived miR-150 is considered as prognostic tool in B cell lymphoma, autoimmune diseases and immune-mediated disorders, suggesting miR-150 plays a vital role in disease onset and progression. In this review, we summarized the miR-150-dependent regulation of B cell function in B cell-related immune diseases.

Keywords: B cells; B-lymphocyte malignancies; autoimmune diseases; exosomes; miR-150.

Publication types

Review

Grants and funding

This research was supported by the Natural Science Foundation of Hunan province (2023JJ10088 to Z-LH) and the National Natural Science Foundation of China (81901231 and 82271379 to Z-LH).