Triple-negative Breast Cancer Arising in a Fibroadenoma in BRCA 1 Mutated Patient

Nicole Brunetti; Irene Valente; Francesca Pitto; Massimo Calabrese

doi:10.4103/jmu.jmu_83_21

Triple-negative Breast Cancer Arising in a Fibroadenoma in BRCA 1 Mutated Patient

J Med Ultrasound. 2022 Aug 16;31(1):63-65. doi: 10.4103/jmu.jmu_83_21. eCollection 2023 Jan-Mar.

Authors

Nicole Brunetti¹, Irene Valente², Francesca Pitto³, Massimo Calabrese³

Affiliations

¹ Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
² AOU Parma Hospital, Parma, Italy.
³ IRCCS Hospital Policlinico San Martino, Genoa, Italy.

Abstract

We describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass, suggestive of a benign lesion. We performed an ultrasound-guided core needle biopsy that demonstrated multiple foci of high-grade (G3) ductal carcinoma in situ arising on fibroadenoma (FA). Subsequently, the patient had surgical excision of the mass with a final diagnosis of triple-negative breast cancer arising on FA. After diagnosis, the patient performs a genetic test that detects the BRCA 1 gene mutation. A review of the literature demonstrated only two cases of triple-negative breast cancer on FA. In this report, we describe another such case.

Keywords: BRCA; breast cancer on fibroadenoma; triple-negative breast cancer.

Publication types

Case Reports