The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Xuelin Wang; Liming Hou; Meng Cui; Junnan Liu; Mengzhou Wang; Jianwu Xie

doi:10.3389/fcimb.2023.1151557

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Front Cell Infect Microbiol. 2023 Apr 25:13:1151557. doi: 10.3389/fcimb.2023.1151557. eCollection 2023.

Authors

Xuelin Wang¹, Liming Hou², Meng Cui¹, Junnan Liu¹, Mengzhou Wang¹, Jianwu Xie¹

Affiliations

¹ School of Food Science and Engineering (School of Biological and Pharmaceutical Sciences), Shaanxi University of Science & Technology, Xi an, China.
² Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi an, China.

Abstract

Non-small cell lung cancer (NSCLC) is one of the most serious diseases affecting human health today, and current research is focusing on gut flora. There is a correlation between intestinal flora imbalance and lung cancer, but the specific mechanism is not clear. Based on the "lung and large intestine being interior-exteriorly related" and the "lung-intestinal axis" theory. Here, based on the theoretical comparisons of Chinese and western medicine, we summarized the regulation of intestinal flora in NSCLC by active ingredients of traditional Chinese medicine and Chinese herbal compounds and their intervention effects, which is conducive to providing new strategies and ideas for clinical prevention and treatment of NSCLC.

Keywords: Chinese herbal compounds; NSCLC; TCM; gut microbiome; lung-gut axis.

Publication types

Review

MeSH terms

Carcinoma, Non-Small-Cell Lung* / drug therapy
Drugs, Chinese Herbal* / therapeutic use
Gastrointestinal Microbiome*
Humans
Lung Neoplasms*
Medicine, Chinese Traditional

Substances

Drugs, Chinese Herbal

Grants and funding

This work was supported by the Natural Science Foundation of China (NSFC:21272214).