Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)

Dorian Culié; Renaud Schiappa; Tanguy Pace-Loscos; Bruno Guelfucci; Sebastien Vergez; Renaud Garrel; Nicolas Fakhry; Olivier Dassonville; Gilles Poissonnet; Benjamin Lallemant; Anne Sudaka; Esma Saada-Bouzid; Karen Benezery; Stephane Temam; Phillipe Gorphe; Emmanuel Chamorey; Alexandre Bozec

doi:10.3390/jcm12093169

Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)

J Clin Med. 2023 Apr 28;12(9):3169. doi: 10.3390/jcm12093169.

Authors

Dorian Culié^{1

2}, Renaud Schiappa², Tanguy Pace-Loscos², Bruno Guelfucci³, Sebastien Vergez⁴, Renaud Garrel⁵, Nicolas Fakhry⁶, Olivier Dassonville¹, Gilles Poissonnet¹, Benjamin Lallemant⁷, Anne Sudaka⁸, Esma Saada-Bouzid⁹, Karen Benezery¹⁰, Stephane Temam¹¹, Phillipe Gorphe¹¹, Emmanuel Chamorey², Alexandre Bozec¹

Affiliations

¹ Antoine Lacassagne Centre, University Institute of the Face and Neck, Côte d'Azur University, 06000 Nice, France.
² Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d'Azur University, 06000 Nice, France.
³ Department of Otorhinolaryngology and Head and Neck Surgery, Sainte Musse Hospital, 83100 Toulon, France.
⁴ Department of Otorhinolaryngology and Head and Neck Surgery, Cancer University Institute of Toulouse, 31100 Toulouse, France.
⁵ Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Montpellier, 34295 Montpellier, France.
⁶ Department of Otorhinolaryngology and Head and Neck Surgery, Public Assistance-Hospitals of Marseille, 13005 Marseille, France.
⁷ Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Nîmes, 30900 Nîmes, France.
⁸ Antoine Lacassagne Centre, Department of Pathology, Côte d'Azur University, 06000 Nice, France.
⁹ Antoine Lacassagne Centre, Department of Medical Oncology, Côte d'Azur University, 06000 Nice, France.
¹⁰ Antoine Lacassagne Centre, Department of Radiotherapy, Côte d'Azur University, 06000 Nice, France.
¹¹ Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, 94805 Villejuif, France.

Abstract

Nutritional support during radiotherapy is crucial to tolerating and completing oropharyngeal squamous cell carcinoma (OPSCC) treatment. The impact of HPV status on nutritional support is debated. The objective was to evaluate the rate of Reactive Feeding Tube (RFT) use and determine its prognostic factors during definitive radiotherapy for OPSCC. All OPSCC patients treated from 2009 to 2014 were included in this multicentric retrospective study. The impact of tumor p16 status on the risk of RFT was assessed through multivariate analyses. Among the 543 patients, 103 patients required an RFT (19.0%). The use of RFT differed between centers (5% to 32.4%). In multivariate analysis, only tongue base involvement and concurrent chemotherapy were significantly associated with RFT (OR = 2.18 and 3.7, respectively). Tongue base involvement and concomitant chemotherapy were prognostic factors for RFT. HPV status was not a prognostic factor for enteral nutrition during radiotherapy for OPSCC.

Keywords: cancer; feeding tube; human papilloma virus; nutrition; oropharynx.

Grants and funding

This research received no external funding.