B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma

Leila Mohammadnezhad; Mojtaba Shekarkar Azgomi; Marco Pio La Manna; Giuliana Guggino; Cirino Botta; Francesco Dieli; Nadia Caccamo

doi:10.3390/ijms24098385

B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma

Int J Mol Sci. 2023 May 7;24(9):8385. doi: 10.3390/ijms24098385.

Authors

Leila Mohammadnezhad^{1

2}, Mojtaba Shekarkar Azgomi^{1

3}, Marco Pio La Manna^{1

3}, Giuliana Guggino², Cirino Botta², Francesco Dieli^{1

3}, Nadia Caccamo^{1

3}

Affiliations

¹ Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP Paolo Giaccone, 90127 Palermo, Italy.
² Department of Sciences for Health Promotion and Mother-Child Care "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
³ Department of Biomedicine, Neuroscience and Advanced Diagnosis (BIND), University of Palermo, 90127 Palermo, Italy.

Abstract

Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells' signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells' signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting CD79A, CD79B, and LAMTOR4 as the shared genes can provide novel biomarkers for pSS progression into lymphoma.

Keywords: BCR; DLBCL; cell signaling; non-hodgkins lymphoma; primary Sjogren syndrome.

MeSH terms

Guanine Nucleotide Exchange Factors
Humans
Lymphoma, Large B-Cell, Diffuse* / genetics
Lymphoma, Large B-Cell, Diffuse* / pathology
Lymphoma, Non-Hodgkin*
Receptors, Antigen, B-Cell / genetics
Signal Transduction
Sjogren's Syndrome* / genetics

Substances

Receptors, Antigen, B-Cell
LAMTOR4 protein, human
Guanine Nucleotide Exchange Factors

Grants and funding

This research received no external funding.