The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Christiana Magkrioti; Eleanna Kaffe; Vassilis Aidinis

doi:10.3390/ijms24098325

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Int J Mol Sci. 2023 May 5;24(9):8325. doi: 10.3390/ijms24098325.

Authors

Christiana Magkrioti¹, Eleanna Kaffe^{1

2}, Vassilis Aidinis¹

Affiliations

¹ Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.
² Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a secreted enzyme with lysophospholipase D activity, with its primary function being the extracellular hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid [...].

Publication types

Editorial

MeSH terms

Embryonic Development
Humans
Lysophospholipids
Neoplasms*
Phosphoric Diester Hydrolases*

Substances

alkylglycerophosphoethanolamine phosphodiesterase
lysophosphatidic acid
Phosphoric Diester Hydrolases
Lysophospholipids

Abstract

Publication types

MeSH terms

Substances

Grants and funding