Positron Emission Tomography/Computed Tomography (PET/CT)-Based, Local Consolidative Radiotherapy after Chemoimmunotherapy in Metastatic, Non-Oncogene-Addicted Non-Small-Cell Lung Cancer (NSCLC)

Lucia Angelini; Montserrat Pazos; Lukas Käsmann; Farkhad Manapov

doi:10.3390/diagnostics13091538

Positron Emission Tomography/Computed Tomography (PET/CT)-Based, Local Consolidative Radiotherapy after Chemoimmunotherapy in Metastatic, Non-Oncogene-Addicted Non-Small-Cell Lung Cancer (NSCLC)

Diagnostics (Basel). 2023 Apr 25;13(9):1538. doi: 10.3390/diagnostics13091538.

Authors

Lucia Angelini^{1

2}, Montserrat Pazos², Lukas Käsmann^{2

3

4}, Farkhad Manapov^{2

3

4}

Affiliations

¹ Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.
² Department of Radiation Oncology, University Hospital, LMU Munich, Ziemsenstrasse 1, 80336 Munich, Germany.
³ German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), 81377 Munich, Germany.
⁴ German Cancer Consortium (DKTK), Partner Site Munich, 81377 Munich, Germany.

Abstract

The optimal sequence of chemo/immuno- and radiotherapy (RT) in metastatic non-small-cell lung cancer (NSCLC) remains challenging. Here, we describe the case of a 58-year-old female patient with an initially metastasized NSCLC obtaining local and distance durable response after chemo-immunotherapy and local RT associated with immunotherapy maintenance. Our experience offers a valuable perspective in choosing how to combine therapies to ensure the longest possible response in patients with estimated poor prognosis.

Keywords: NSCLC 1; PET/CT 3; multimodal treatment 2.

Grants and funding

This research received no external funding.