TET2, tumor control, and CAR T cell hyperproliferation

Trends Cancer. 2023 Jul;9(7):521-523. doi: 10.1016/j.trecan.2023.04.009. Epub 2023 May 11.

Abstract

A recent study by Jain et al. published in Nature followed up on evidence suggesting that depletion of 5-methylcytosine dioxygenase TET2 in chimeric antigen receptor CAR T cells could enhance their expansion, persistence, and antitumor efficacy. Their findings are cautionary, but offer hope of a path forward.

Keywords: CAR; T cell; TET2; clonal; hyperproliferation; lymphocyte.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Proliferation
  • DNA-Binding Proteins / genetics
  • Dioxygenases*
  • Humans
  • Immunotherapy, Adoptive
  • Neoplasms* / therapy
  • Receptors, Chimeric Antigen* / genetics
  • T-Lymphocytes

Substances

  • Receptors, Chimeric Antigen
  • TET2 protein, human
  • DNA-Binding Proteins
  • Dioxygenases