NIR- and pH-responsive injectable nanocomposite alginate-graft-dopamine hydrogel for melanoma suppression and wound repair

Ping Li; Yang Li; Rongzhan Fu; Zhiguang Duan; Chenhui Zhu; Daidi Fan

doi:10.1016/j.carbpol.2023.120899

NIR- and pH-responsive injectable nanocomposite alginate-graft-dopamine hydrogel for melanoma suppression and wound repair

Carbohydr Polym. 2023 Aug 15:314:120899. doi: 10.1016/j.carbpol.2023.120899. Epub 2023 Apr 14.

Authors

Ping Li¹, Yang Li¹, Rongzhan Fu¹, Zhiguang Duan¹, Chenhui Zhu², Daidi Fan³

Affiliations

¹ Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, Shaanxi, China.
² Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, Shaanxi, China. Electronic address: zch2005@nwu.edu.cn.
³ Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, Shaanxi, China. Electronic address: fandaidi@nwu.edu.cn.

PMID: 37173039
DOI: 10.1016/j.carbpol.2023.120899

Abstract

Surgical excision, chemotherapy, and radiotherapy are the main approaches used for treating melanoma. Unfortunately, surgical excision usually inevitably causes large area skin defects. In addition, chemotherapy and radiotherapy are often accompanied by adverse reactions and multi-drug resistance. To overcome these limitations, a near-infrared (NIR)- and pH-responsive injectable nanocomposite hydrogel was developed using sodium alginate-graft-dopamine (SD) and biomimetic polydopamine-Fe(III)-doxorubicin nanoparticles (PFD NPs) for treating melanoma and promoting skin regeneration. Firstly, the SD/PFD hydrogel can precisely deliver anti-cancer agents to the tumor site to reduce its loss and off-target toxicity. Then, PFD can convert light into heat energy under NIR irradiation to kill cancer cells. Meanwhile, doxorubicin can be administered continuously and controllably by NIR- and pH-responsive. Additionally, the SD/PFD hydrogel can also relieve tumor hypoxia by decomposing endogenous hydrogen peroxide (H₂O₂) into oxygen (O₂). Therefore, photothermal, chemotherapy, and nanozyme synergetic therapy resulted in the tumor suppression. Specifically, the SA-based hydrogel can kill bacteria, scavenge reactive oxygen species, promote the proliferation and migration of cells, and significantly accelerate skin regeneration. Therefore, this study provides a safe and effective strategy for melanoma treatment and wound repair.

Keywords: Melanoma; NIR- and pH-responsive drug delivery; Polydopamine; Sodium alginate; Synergistic therapy; Wound healing.

MeSH terms

Dopamine*
Doxorubicin
Ferric Compounds
Humans
Hydrogels / pharmacology
Hydrogen Peroxide
Hydrogen-Ion Concentration
Melanoma* / drug therapy
Nanogels

Substances

Nanogels
Dopamine
Ferric Compounds
Hydrogen Peroxide
Doxorubicin
Hydrogels