Application of chitosan with different molecular weights in cartilage tissue engineering

Runjie Zhang; Shwu Jen Chang; Yanzhen Jing; LiYuan Wang; Ching-Jung Chen; Jen-Tsai Liu

doi:10.1016/j.carbpol.2023.120890

Application of chitosan with different molecular weights in cartilage tissue engineering

Carbohydr Polym. 2023 Aug 15:314:120890. doi: 10.1016/j.carbpol.2023.120890. Epub 2023 Apr 11.

Authors

Runjie Zhang¹, Shwu Jen Chang², Yanzhen Jing¹, LiYuan Wang¹, Ching-Jung Chen³, Jen-Tsai Liu⁴

Affiliations

¹ Research Center for Materials Science and Opti-Electronic Technology, College of Materials Science and Opti-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
² Department of Biomedical Engineering, I-Shou University, Kaohsiung City 82445, Taiwan.
³ Research Center for Materials Science and Opti-Electronic Technology, School of Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: cjchen@ucas.ac.cn.
⁴ Research Center for Materials Science and Opti-Electronic Technology, College of Materials Science and Opti-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: jtliu@ucas.ac.cn.

PMID: 37173038
DOI: 10.1016/j.carbpol.2023.120890

Abstract

Cartilage tissue engineering involves the invention of novel implantable cartilage replacement materials to help heal cartilage injuries that do not heal themselves, aiming to overcome the shortcomings of current clinical cartilage treatments. Chitosan has been widely used in cartilage tissue engineering because of its similar structure to glycine aminoglycan, which is widely distributed in connective tissues. The molecular weight, as an important structural parameter of chitosan, affects not only the method of chitosan composite scaffold preparation but also the effect on cartilage tissue healing. Thus, this review identifies methods for the preparation of chitosan composite scaffolds with low, medium and high molecular weights, as well as a range of chitosan molecular weights appropriate for cartilage tissue repair, by summarizing the application of different molecular weights of chitosan in cartilage repair in recent years.

Keywords: Cartilage tissue engineering; Cell-material interactions; Chitosan composites; Different molecular weights.

Publication types

Review

MeSH terms

Cartilage
Chitosan* / chemistry
Molecular Weight
Tissue Engineering
Tissue Scaffolds / chemistry

Substances

Chitosan