Gut microbiota-metabolic axis insight into the hyperlipidemic effect of lotus seed resistant starch in hyperlipidemic mice

Hongliang Zeng; Shuqi He; Zixiao Xiong; Jinhan Su; Yanbo Wang; Baodong Zheng; Yi Zhang

doi:10.1016/j.carbpol.2023.120939

Gut microbiota-metabolic axis insight into the hyperlipidemic effect of lotus seed resistant starch in hyperlipidemic mice

Carbohydr Polym. 2023 Aug 15:314:120939. doi: 10.1016/j.carbpol.2023.120939. Epub 2023 Apr 27.

Authors

Hongliang Zeng¹, Shuqi He², Zixiao Xiong², Jinhan Su², Yanbo Wang³, Baodong Zheng², Yi Zhang⁴

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zhlfst@fafu.edu.cn.
² College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
³ School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
⁴ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zyifst@fafu.edu.cn.

PMID: 37173019
DOI: 10.1016/j.carbpol.2023.120939

Abstract

We investigated the hyperlipidemic effect of different doses of lotus seed resistant starch (low-, medium and high-dose LRS, named as LLRS, MLRS and HLRS, respectively) in hyperlipidemic mice using gut microbiota-metabolic axis compared to high-fat diet mice (model control group, MC). Allobaculum was significantly decreased in LRS groups compared to MC group, while MLRS promoted the abundance of norank_f_Muribaculaceae and norank_f_Erysipelotrichaceae. Moreover, supplementation of LRS promoted cholic acid (CA) production and inhibited deoxycholic acid compared to MC group. Among, LLRS promoted formic acid, MLRS inhibited 20-Carboxy-leukotriene B4, while HLRS promoted 3, 4-Methyleneazelaic acid and inhibited Oleic acid and Malic acid. Finally, MLRS regulate microbiota composition, and this promoted cholesterol catabolism to form CA, which inhibited serum lipid index by gut microbiota-metabolic axis. In conclusion, MLRS can promote CA and inhibit medium chain fatty acids, so as to play the best role in lowering blood lipids in hyperlipidemia mice.

Keywords: Gut microbiota-metabolic axis; Hyperlipidemic mice; Lotus seed resistant starch; Serum lipid index; Untargeted metabolites.

MeSH terms

Animals
Diet, High-Fat
Gastrointestinal Microbiome*
Lipids
Mice
Microbiota*
Resistant Starch
Seeds

Substances

Resistant Starch
Lipids